ABSTRACT
Objective To analyze the epidemiological characteristics of hepatitis B in Guangzhou from 2006 to 2018. Methods The data were retrieved from the National Infectious Disease Surveillance Information Report Management System. Descriptive methods were used to analyze and summarize the results. Chi-square test was used for statistical analysis of classification data, and Joinpoint software was used to analyze the annual change percentage and trend. Results A total of 292 674 cases of hepatitis B were reported in Guangzhou from 2006 to 2018, and the annual average reported incidence was 182.2 per 100,000. Chronic hepatitis B was the main type, accounting for 89.9%. The incidence rate of males (241.6 / 105) was higher than that of females (117.9 / 105), with a ratio of 2.0:1. During the period from 2006-2018, the reported incidence of hepatitis B in Guangzhou first increased, reached the highest in 2008, and then decreased year by year. There was no significant difference in the number of HBV cases among different months. The average onset age of hepatitis B reported in Guangzhou was 39.3 years old, and the average onset age increased year by year from 2006 to 2018. Conclusion The incidence rate of hepatitis B in Guangzhou has decreased since 2008, but it was still higher than the national average incidence rate. The hepatitis B infection in Guangzhou remains a big issue. It is suggested to further strengthen the prevention and control of hepatitis B in adults by maintaining a national immunization program for children, thereby reducing the epidemiological level of hepatitis B in Guangzhou.
ABSTRACT
Objective To study the effect of nitrobenzene(NB) on the activity of enzymes and the content of zinc in the testis tissue of mice. Methods 40 male mice were divided into 4 groups, 10 in each, 3 groups were treated with NB at the doses of 2, 20, 200 mg/kg by gavage, the control group was treated with vegetable oil in the same volume, once a day, for 21 consecutive days. The activity of G-6-PD, LDH and the content of Zn2+ in testis cells were determined. Results The index of epididymis and testis in the groups of 200 mg/kg were significantly lower compared with the control and 2 mg/kg group (P0.05). The activity of G-6-PD, LDH and the content of Zn2+ in all the treated groups were lower than those in the control group (P